Accupril, which is quinapril, medication with hypotensive, natriuretic, cardio-protecting effect and vasodilating properties. It is used in case of an arterial hypertension (mono- or combined therapy), heart failure (combined therapy).
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Accupril product description
Drug uses
Accupril is prescribed to patients suffering from hypertension. It is prescribed by doctors as a monotherapy and also in combination of thiazide diuretics together with beta-adreno-blockers. And also in case of heart failure, expressed in the chronic form (in combination with diuretics and cardiac glycosides) The drug has many excellent responses from patients who took it for treatment.
These pills contain an enzyme in their composition which conduces to the process of narrowing vessels simultaneously increasing their tone. This result is achieved due to the adrenal cortex, which contributes to the production of aldosterone.
Accupril safety information
Tablets should be taken in a holistic form (do not chew them), without binding to the time of ingestion. With arterial hypertension, as a monotherapy. As it is stated in the medical recommendation, the patient should take usually 10 mg of Accupril per day. Taking into account the level of clinical effect, it is possible to increase the dosage to 20-40mg. Such a dosage can be prescribed for taking 1-2 times per day. The dosage should be changed at intervals of 4 weeks. The highest possible daily dosage may be approximate to 80mg. With a combined form of therapy with diuretics, take 5mg per day. Perhaps a gradual increase to achieve the desired therapeutic effect. With heart failure (a chronic form) you need to take one pill of 5mg, twice a day. Next, the state of your body should be under control of a healthcare specialist to determine the arterial hypotension (symptomatic). With a positive result, you can increase the dosage which you take to 10-40mg per day, dividing it into two equal doses. In case of failures of kidney function, the dosage depends on the quantitative values of the creatinine clearance value. 10 mg can be taken if the value is above 60 ml/min; dosage of 5 mg, if the value is from 30 to 60 ml/min; a dosage of 2.5 mg, with a value of 10 to 30 ml/min.
Precautionary measures
The remedy is not assigned to patients with angioedema, anuria, Quincke edema (idiopathic, hereditary), Addison's disease, diabetes, patients under the age of 18, renal insufficiency in severe form (creatinine clearance is below 30 ml/min); sensitivity to the components of the remedy.
During the treatment with the remedy, cases of angioedema appeared, so if there appear any kind of symptoms of it, stop taking this medication. In a case when surgery is planned, the surgeon or anesthesiologist should be warned about taking an ACE inhibitor, like Accupril.
Accupril side effects
Among the most frequent adverse reactions there are:
a headache, insomnia, depression, nausea, swelling, marked lowering of blood pressure, tachycardia, back pain, infections of the urinary tract, blurred vision, hemolytic anemia.
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The medicine belongs to the group of cardiac glycosides. The preparation obtained from the medicinal plants' Woolly Foxglove. It has the following actions: inotropic, vasodilator and moderate diuretic. The pills increase the concussive and systolic volume of the heart, increases the refractory period, reduces atrioventricular conduction, reduces the frequency of contractions of the heart muscle. In the case of stagnation in cardiovascular insufficiency, it has a pronounced vasodilating effect. Lanoxin has a mild diuretic effect, reduces the severity of edema. Overdosage may trigger an increase in the excitability of the myocardium, resulting in disturbances of heart rhythm.
