Zoloft is an antidepresant stopping the reuptake of serotonin, which is performed by the neurons that isolated it. As a result, the concentration of the neurotransmitter increases in the synaptic cleft and the main cause of depressive states, the serotonin deficiency, is eliminated.
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Product description
Sertralin is an active ingredient in Zoloft. It stops the reuptake of serotonin, which is performed by the neurons that have isolated it. As a result, the concentration of the neurotransmitter increases in the synaptic cleft and the main cause of depressive states, the serotonin deficiency, is eliminated.
The effect on serotonin receptors causes a significant correction of the mental state of patients with depression. It manifests itself in heightening the mood, eliminating phobias, anxious states, reducing feelings of anguish, and reducing appetite. The drug acts on 5-HT receptors. On the reagent of norepinephrine, dopamine is weakly affected. There was no sedative, cardiotoxic effect, anticholinergic effect and stimulation effect. Zoloft does not provoke the formation of dependence. Long-term therapy can lead to a decrease in the activity of adrenaline receptors in the brain.
Indications
Zoloft is prescribed for the treatment and prevention of relapses with:
- Depressive states;
- social phobia;
- obsessive-compulsive disorder (ROC);
- depression with manic conditions;
- panic disorder;
With depression with a sense of anxiety;
- panic disorder with agoraphobia;
- posstraumatic depressive disorders.
Safety information
Zoloft tablets are taken orally. The dose should be prescribed by the doctor and usually is consumed in the morning or evening, once a day. There is no affect on efficacy from Zoloft depending on type of food or the time of your meal.
Contraindications
- Known hypersensitivity to sertraline;
- Simultaneous use of MAO inhibitors and pimozide;
- Pregnancy;
- The period of breastfeeding;
- Children under 6 years;
- Organic diseases of the brain (including delay in mental development);
- Epilepsy;
- Hepatic and / or renal insufficiency;
- Pronounced weight loss.
- On the part of the digestive system: flatulence, nausea, vomiting, diarrhea, constipation, abdominal pain, pancreatitis, dry mouth.
- Cardiovascular: palpitations, tachycardia, hypertension.
- From the musculoskeletal system: arthralgia, muscle cramps.
- From the side nervous system: dyskinesias, akathisia, gnashing of teeth, gait disturbance, involuntary muscular contractions, paresthesia, fainting, drowsiness, headache, migraine, dizziness, tremor, insomnia, anxiety, agitation, hypomania, mania , Hallucinations, euphoria, nightmares, psychosis, decreased libido, suicide, coma.
- On the part of the respiratory system: bronchospasm, yawning.
- From the urinary system: enuresis, urinary incontinence or retention
- On the part of the reproductive system and breast: a violation of sexual function (delay ejaculation, decreased potency), galactorrhea, gynecomastia, menstrual irregularity, priapism.
- On the part of the organs of vision: visual impairment, mydriasis.
- On the part of the endocrine system: Hyperprolactinaemia, hypothyroidism, the syndrome of inadequate secretion of ADH.
- From the hepatic system: hepatitis, jaundice, liver failure.
- Allergic reactions: urticaria, pruritus, anaphylactoid reaction
- Other: weakness, redness of the skin or flushing of the face, ringing in the ears, alopecia, angiooedema, facial edema, periorbital edema, photosensitivity reaction, purpura, increased sweating, decreased appetite (rarely increased), down to anorexia, decrease or increase Body weight, bleeding (including nasal, gastrointestinal or hematuria), peripheral edema, occasionally Stevens-Johnson syndrome and epidermal necrolysis.
- Possible development of leukopenia and thrombocytopenia, as well as increased serum cholesterol levels.
Side effects
- On the part of the digestive system: flatulence, nausea, vomiting, diarrhea, constipation, abdominal pain, pancreatitis, dry mouth.
- Cardiovascular: palpitations, tachycardia, hypertension.
- From the musculoskeletal system: arthralgia, muscle cramps.
- From the side nervous system: dyskinesias, akathisia, gnashing of teeth, gait disturbance, involuntary muscular contractions, paresthesia, fainting, drowsiness, headache, migraine, dizziness, tremor, insomnia, anxiety, agitation, hypomania, mania , Hallucinations, euphoria, nightmares, psychosis, decreased libido, suicide, coma.
- On the part of the respiratory system: bronchospasm, yawning.
- From the urinary system: enuresis, urinary incontinence or retention
- On the part of the reproductive system and breast: a violation of sexual function (delay ejaculation, decreased potency), galactorrhea, gynecomastia, menstrual irregularity, priapism.
- On the part of the organs of vision: visual impairment, mydriasis.
- On the part of the endocrine system: Hyperprolactinaemia, hypothyroidism, the syndrome of inadequate secretion of ADH.
- From the hepatic system: hepatitis, jaundice, liver failure.
- Allergic reactions: urticaria, pruritus, anaphylactoid reaction
- Other: weakness, redness of the skin or flushing of the face, ringing in the ears, alopecia, angiooedema, facial edema, periorbital edema, photosensitivity reaction, purpura, increased sweating, decreased appetite (rarely increased), down to anorexia, decrease or increase Body weight, bleeding (including nasal, gastrointestinal or hematuria), peripheral edema, occasionally Stevens-Johnson syndrome and epidermal necrolysis.
- Possible development of leukopenia and thrombocytopenia, as well as increased serum cholesterol levels.
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