The anti-malarial drug from the group of 8-aminohinolina derivatives. It is characterized by intercalation with DNA plasmodia, leading to disruption of nucleic acids synthesis. It demonstrates high activity against exo-erythrocytic forms of all types of malaria, including primary tissue and para- erythrocyte forms. Particularly active against primary tissue forms of Plasmodium falciparum.
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Primaquine product description
Primaquine, it is released in the form of diphosphate. It is a fine crystalline powder of a bright yellow color, bitter in taste, soluble in water. It has an antiprotozoal effect on the sexual forms, schizonts and para-erythrocytic forms of all forms of malaria plasmoids. Applied for the prevention of long-term recurrences with three- and four-day and tropical malaria. In addition, prescribed for personal chemoprophylaxis in combination with Chingaminum (chloroquine), as well as for public chemoprophylaxis.
Primaquine safety information
Among the population of some areas of the Mediterranean, the Caucasus, and Africa (particularly often) there are people with congenital lack of glucose-6-phosphate dehydrogenase, therefore in these areas the primaquine should be consumed with an extreme caution, not exceeding the daily dose of 0.015 g based on the base (0.027 g diphosphate) for an adult; in the process of treatment, the accurate monitoring of the patient is necessary.
Primaquine should not be taken simultaneously with the Acrichinum (the Primaquine tablet is retained in the blood, and therefore its toxicity enhances) and during the shortest time after taking the Acrichinum (due to the slow release of Acrichinum from the body) and also with drugs that can exert hemolytic action and inhibit myeloid elements bone marrow (sulfonamides, etc.).
Primaquine is contraindicated for persons with acute infectious diseases (except malaria), during an exacerbation of rheumatism and other diseases characterized by a tendency to granulocytopenia, with blood and hematopoietic diseases, kidney illness, angina pectoris. It is impossible to cure with a help of Primaquine simultaneously with drugs that depress hemopoiesis.
Primaquine side effects
In the majority of cases this medical agent is well tolerated, but occasionally during the course of pharmaceutical, there may appear the pain in the abdomen, dyspepsia, pain in the heart; general weakness, cyanosis (methemoglobinemia). These phenomena occur after the drug course is discontinued. Children should get the prescription just being under severe control during the treatment procedure. An acute intravascular hemolysis with the hemoglobinuria may manifest in people with a lack of erythrocyte in the enzyme glucose-6-phosphate dehydrogenase. In severe cases, the picture resembles hemoglobinuric fever.
When prescribing the Primaquine tablets to patients with symptoms of anemia and with suspicion of anemia, an abnormality of red blood cells should be carefully regulated and the examination of the state of the blood and urine should be conducted as well. At the first signs of a change in the color of urine, a sharp decrease in the content of hemoglobin or a change in the number of white blood cells, the course of the treatment with Primaquine has to be immediately canceled.
Levitra - the main component - the active agent Vardenafil which promotes strengthening of blood circulation in generative organs of men. It allows to reach a high level erection at sexual stimulation, and also to increase sensitivity of head of a penis and to make sexual intercourse longer and more pleasant. The main feature of a drug Levitra - quickness of effect, duration of impact on an organism up to 12 hours and a very small number of side effects.
Cialis Super Active is a generic drug, against erectile dysfunction, containing 20 mg of tadalafil. The tablets in this series have a gel inside. This form allows the active substance, Tadalafil, to immediately enter the blood, thus providing an immediate effect. The result from the Cialis Super Active tablets appears after 5 minutes! The action lasts for two days. The drug is safe and has virtually no contraindications.
Viagra - Active ingredient - Sildenafil, 100 mg. Effect of "Viagra" is based on significant increase of blood stream to penis. Begins to work in 30 minutes, the effect lasts for 4-5 hours. Most of men can take this generic viagra every day. Millions of men worldwide cannot be mistaken, choosing Viagra!
Albenza - anthelmintic agent which is active concerning adult individuals and larval forms. Albendazole influences polymerization of β-tubulin, which stops it. As a result, occurs violation of formation of microtubules in intestines of helminths, the ability of vermis to acquire glucose is suppressed. It is blocked the normal intracellular migration of organellas, and it is prevented the synthesis of ATP in their muscular tissue. Creation of therapeutic concentration of albendaloze leads to death of helminths. Medicine causes death of nematodes (Necator americanus, Strongyloides stercoralis, Enterobius vermicularis, Trichuris trichiura, Ascaris lumbricoides, Cutaneous Larva Migrans, Ancylostoma duodenale), cestode (pig, bull and dwarf tapeworm), trematode (Clonorchis sinensis, Opisthorchis viverrini), elementary (Lamblia).
Flagyl - antiprotozoan and antimicrobic drug. It is prescribed at treatment of protozoan inspections (abenteric amebiasis, including amoebic abscess of liver, an intestinal amebiasis, trichomoniasis, giardiasis, balanthidiasis, lambliasis, skin leushmaniosis, mecotic vaginitis, mecotic urethritis), pseudomembranous colitis, gastritises, ulcer, prevention of postoperative complications (especially interventions at segmented intestine, perirectal area, appendectomy, gynecologic operations).
Mobic is a nonsteroidal anti-inflammatory drug, which has anti-inflammatory, antipyretic, analgesic effect. It belongs to the class of oxicams; derived from the anoliefo acid. Used in symptomatic treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis (Bekhterev's disease) and other inflammatory and degenerative diseases, accompanied by pain syndrome.
Xeloda is a cytostatic drug. The drug is used for the treatment of patients with metastatic or locally advanced breast cancer, including after an ineffective chemotherapy course, which included anthracycline drugs and taxanes, and also if the patient has contraindications to anthracyclines.
