Free Shipping on All orders Over $200!
stock-banner
Only In December
10% off
orders over $222

Use promo code HAPPY on your most loved items!

stock-banner
Only In December
FREE bonus
Pills for every order

Free Shipping on orders Over $200!

stock-banner
Only In December
Free Shipping
on All orders Over $200!

Free Shipping on orders Over $200!

Search by name:
All A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Other
Methotrexate
Methotrexate
Active ingredient: Methotrexate

Methotrexate belongs to the group of antimetabolites with cytostatic activity. It inhibits the conversion of dihydrofolic acid into tetrahydrofolic acid. Thymidylic acid and purine synthesis are disrupted, which, in turn, suppresses DNA synthesis and cell division. The maximum absorption of the medicine is observed after 30 to 60 minutes. The drug is metabolized by enzymes of the intestinal microflora, hepatocytes, and other cells.

We accept: visa mastercard sepa bitcoin ethereum
item_photo item_photo
item_photo item_photo
item_photo item_photo
item_photo item_photo
zoom
December
8
airmail
Delivery period
14-21 days
$9.95
Tracking# available in 14 days
ems
Delivery period
14-21 days
$29.95
Tracking# available in 5 days
Availability:In Stock 89 packs
Methotrexate 10
Package Per pill Total price Save Order
10 x 10 Pills $5.63
$56.34
+ Bonus - 4 Pills
- Add to cart
10 x 20 Pills $4.44
$88.82
+ Bonus - 4 Pills
$23.80 Add to cart
10 x 30 Pills $4.04
$121.29
+ Bonus - 4 Pills
$47.70 Add to cart
10 x 60 Pills $3.65
$218.74
+ Bonus - 4 Pills
Free Trackable Delivery
$118.80 Add to cart
10 x 90 Pills $3.51
$316.17
+ Bonus - 7 Pills
Free Trackable Delivery
$190.80 Add to cart
10 x 120 Pills $3.45
$413.60
+ Bonus - 7 Pills
Free Trackable Delivery
$261.60 Add to cart
10 x 180 Pills $3.38
$608.47
+ Bonus - 11 Pills
Free Trackable Delivery
$405.00 Add to cart
Methotrexate 5
Package Per pill Total price Save Order
5 x 10 Pills $3.60
$36.00
+ Bonus - 4 Pills
- Add to cart
5 x 20 Pills $2.95
$58.91
+ Bonus - 4 Pills
$13.00 Add to cart
5 x 30 Pills $2.73
$81.83
+ Bonus - 4 Pills
$26.10 Add to cart
5 x 60 Pills $2.51
$150.58
+ Bonus - 4 Pills
$65.40 Add to cart
5 x 90 Pills $2.44
$219.32
+ Bonus - 7 Pills
Free Trackable Delivery
$104.40 Add to cart
5 x 120 Pills $2.40
$288.07
+ Bonus - 7 Pills
Free Trackable Delivery
$144.00 Add to cart
5 x 180 Pills $2.36
$425.57
+ Bonus - 11 Pills
Free Trackable Delivery
$223.20 Add to cart
5 x 270 Pills $2.34
$631.80
+ Bonus - 11 Pills
Free Trackable Delivery
$340.20 Add to cart
Methotrexate 2.5
Package Per pill Total price Save Order
2.5 x 30 Pills $1.76
$52.65
+ Bonus - 4 Pills
- Add to cart
2.5 x 60 Pills $1.42
$85.19
+ Bonus - 4 Pills
$20.40 Add to cart
2.5 x 90 Pills $1.31
$117.75
+ Bonus - 7 Pills
$40.50 Add to cart
2.5 x 120 Pills $1.25
$150.29
+ Bonus - 7 Pills
$61.20 Add to cart
2.5 x 180 Pills $1.20
$215.39
+ Bonus - 11 Pills
Free Trackable Delivery
$100.80 Add to cart
2.5 x 270 Pills $1.16
$313.03
+ Bonus - 11 Pills
Free Trackable Delivery
$162.00 Add to cart
2.5 x 360 Pills $1.14
$410.67
+ Bonus - 11 Pills
Free Trackable Delivery
$223.20 Add to cart
Package Example

Your order will be packed safe and secure and dispatched within 24 hours. This is exactly how your parcel will look like (pictures of a real shipping item). It has a size and a look of a regular private letter (9.4x4.3x0.3 inches or 24x11x0.7cm) and it does not disclose its contents

Front View
package-front
Side View
package-side
Back View
package-back

The pills are a component of the group of antimetabolites with cytostatic activity. They reduce the change of dihydrofolic acid in tetrahydrofolic acid.


Product Description


There are changes in Timpilo acid and purine, which in turn changes the connection of DNA and division of cells, the connection of RNA and protein. The peculiarity of the drug is in the s-phase of the cell cycle. The most sensitive to the drug are tissues with high proliferative potential (tumor tissue, bone marrow, epithelial cells, and fetal cells).

After 30 to 60 minutes, administration to the muscle has the highest concentration. The drug is well dispersed in body tissues, as well as in ascitic and pleural fluids. The kidney tissue is determined in several weeks and the tissues of the liver, for three months. When the pills are used in medium amounts, they do not penetrate the blood-brain barrier. It is metabolized by enzymes of the intestinal microflora, hepatocytes and other cells with the formation of active metabolite – pollutant (inhibitor of dihydrofolate reductase and timdelaghetto).

The terminal half-life time is dose-dependent and lasts from three to ten hours and eight to fifteen hours when using small and large doses of the drug. 90% of the received dose comes out with urine in its present form by glomerular filtration and active tubular secretion and only ten percent – within 24 hours with bile (followed by reabsorption in the intestine).

The components mostly come out with urine and its characteristics do not change. When the activity of kidney function is impaired, the elimination of methotrexate decreases speed, while its concentration in the blood plasma increases. The components could be released into breast milk.


Safety information


The pills cannot be combined with strong oxidants and acids. If they are mixed with chlorpromazine hydrochloride, droperidol, metoclopramide hydrochloride, heparin solution, prednisolone sodium phosphate and hydrochloride promethazine it would be possible to obtain its turbidity or precipitate formation.

The amount is calculated according to the weight of the person or the surface area of the skin. The tablets are effective in case of a large number of cancers as a monotherapy, and in combination with other chemotherapy drugs.


Side Effects


The pills have a negative impact on the blood system: it inhibits bone marrow function (as a result it leads to infection, sepsis, bleeding), thrombocytopenia, leukopenia, anemia, and hematoma. In the digestive system, there are such problems as gingivitis, stomatitis, pharyngitis, nausea may appear, and the patient often goes to the toilet experiencing stomach disorders. Sometimes people taking this drug feel a violation of liver function. There a liver dystrophy, erosive and ulcerative disorders of the mucous membrane of the stomach and intestines, and a liver failure may happen.

As for disorders in the nervous system, a person has a headache, dizziness, vision impairment, hemiparesis, seizures. After intrathecal administration, the pressure of cerebrospinal fluid increases. In the genitourinary system: a person starts to suffer from cystitis, azotemia, hematuria, women have the menstrual disorder, infertility, vaginal, spontaneous abortion, teratogenic effect, decreased libido, impotence, ovogenesis, spermatogenesis. Pills can lead to negative consequences of the skin such as rash, skin can itch, acne, furunculosis develops. Sometimes there is a Stevens-Johnson syndrome.

Recently viewed
Erectile Dysfunction

Viagra Professional - Advantage of Professional Viagra from usual Viagra is that it works twice longer (6 - 8 hours) and has a stronger effect. Strengthens desire, improves brightness of sexual feelings and increases duration of sexual intercourse.

Viagra Professional Viagra Professional
$0.51
Per pill
Add to cart
Bestsellers
Erectile Dysfunction

Brand Levitra – a drug from Bayer, with a basic chemical called Vardenafil, is an improved remedy for treating erectile difficulties. Operates approximately within 6-8 hours, so a man may be ready to perform sexually the whole night.

Brand Levitra Brand Levitra
$3.33
Per pill
Add to cart
Today’s sale
Erectile Dysfunction

Super ED Trial Pack (6 Viagra + 6 Cialis + 6 Levitra) - a set sampler of Super ED Trial Pack generics which was created at numerous requests of customers. The set comprises 6 tablets (of big popularity) for solution of men's intimate problems. The set consist of: Viagra 100 mg, Cialis (20 mg) and Levitra (20 mg) that is production of well known Indian companies. All medicine of the Super ED Trial Pack set contain optimum doses of active agent and therefore you can take it for several times. Besides, it is quite possible to save money, having divided each tablet into parts.

Super ED Trial Pack Super ED Trial Pack
$2.89
Per pill
Add to cart
Erectile Dysfunction

ED Trial Pack (2 Viagra + 2 Cialis + 2 Levitra) - a trial set consists of six tablets, for those who want to understand what medicine is better for him. Includes 6 tablets (by 2 pсs.): Viagra, Cialis and Levitra. It can be taken by people older than 18 years, in case of problems in private life related to fatigue, stress, sleep debt, slow-moving way of life and abuse of addictions.

ED Trial Pack ED Trial Pack
$4.12
Per pill
Add to cart
Erectile Dysfunction

Super ED Trial Pack (6 Viagra + 6 Cialis + 6 Levitra) - a set sampler of Super ED Trial Pack generics which was created at numerous requests of customers. The set comprises 6 tablets (of big popularity) for solution of men's intimate problems. The set consist of: Viagra 100 mg, Cialis (20 mg) and Levitra (20 mg) that is production of well known Indian companies. All medicine of the Super ED Trial Pack set contain optimum doses of active agent and therefore you can take it for several times. Besides, it is quite possible to save money, having divided each tablet into parts.

Super ED Trial Pack Super ED Trial Pack
$2.89
Per pill
Add to cart
Erectile Dysfunction

Brand Levitra – a drug from Bayer, with a basic chemical called Vardenafil, is an improved remedy for treating erectile difficulties. Operates approximately within 6-8 hours, so a man may be ready to perform sexually the whole night.

Brand Levitra Brand Levitra
$3.33
Per pill
Add to cart
advantages
Free Regmail
All Orders From $200
*Limited Time Offer
advantages
Free ems Regmail
All Orders From $200
*Limited Time Offer
advantages
1m+ Customers
Quality, Privacy, Secure.
advantages
Very Low Prices
Best price in the world!
advantages
Fast Delivery
100% Guarantee. Free Airmail shipping.